PIPELINE

Innovative, Systems Biology Medicines

Pre-clinical

Phase I

Phase IIa

Phase IIb

Phase III

Indication

Pre-clinical Phase I Phase IIa Phase IIb Phase III

Liver Cancer

YIV-906 + Sorafenib: Treating Hepatitis B(+) Hepatocellular Carcinoma Patients
YIV-906 + Capecitabine
YIV-906 + Anti-PD-1

Pancreatic Cancer

YIV-906 + Capecitabine

Colorectal Cancer

YIV-906 + Irinotecan
YIV-906 + Irinotecan / Fluorouracil / Leucovorin

Rectal Cancer

YIV-906 + Chemo-Radiation

Non-Small Cell Lung Cancer

YIV-906 + Anti-PD-1

Melanoma

YIV-906 + Anti-PD-1
YIV-906 + Anti-PD-1/CTLA-4
YIV-906 + Anti-PD-L1

Inflammatory Bowel Disease

YIV-906

Irritable Bowel Syndrome

YIV-906

Lung Cancer

YIV-111

Pulmonary Fibrosis

YIV-111

Breast Cancer

YIV-818

Prostate Cancer

YIV-818

Indication: Solid Tumors (as adjuvant)

  • Promising clinical data suggests that YIV-906 could help prolong survival and improve quality of life.
  • YIV-906 could become the backbone for cancer therapies – by improving the therapeutic index for a broad spectrum of cancer regimens, including immunotherapies, cell therapies, chemotherapies, and radiation.

Mechanisms of Action: Immunomodulator + Cytoprotector

  • YIV-906 turns cold tumors hot and potentiates anti-tumor activity by acting as immumomodulator in the tumor microenvironment
    • priming the tumor microenvironment,
    • overcoming immune resistance,
    • enhancing innate immunity,
    • enhancing adaptive immunity
  • YIV-906 helps reduce non-hematological side-effects and speed up recovery by acting as a cytoprotector in the GI by:
    • reducing intestinal inflammation,
    • promoting damaged tissue repair

Regulatory Status

  • FDA has granted two Orphan Drug Designations for hepatocellular carcinoma and pancreatic cancer.

Current Clinical Trial – Completed 2025

  • Enrolling hepatocellular carcinoma patients with hepatitis B (+) in a Phase 2b clinical study, in the US, Mainland China, Hong Kong, and Taiwan

Indication: Inflammatory Bowel Disease (IBD)

  • YIV-906 could improve quality of life for IBD patients

Mechanisms of Action: Cytoprotector

  • YIV-906 acts as a cytoprotector in the GI by:
    • reducing intestinal inflammation,
    • promoting mucosal barrier healing,
    • modulating bacteria,
    • managing pain,
    • reducing colitis pathology

Indications: Respiratory Diseases

  • YIV-111 could prevent or treat lung diseases and their progression (from chronic inflammation to pulmonary fibrosis to cancer)

Mechanisms of Action

  • YIV-111 acts on multiple targets to:
    • reduce inflammation
    • reduce fibrosis
    • reduce oxidative stress
    • reduce bacterial virulence
    • reduce viral virulence

Indications: Hormone-driven Diseases

  • YIV-818 is a first-in-class systems biology drug that could hormone-driven cancers and their disease progression
  • YIV-818-A (Men’s Health): prevents and treats prostate cancer. Potential to:
    • boost the efficacy of androgen receptor drugs (including enzalutamide, apalutamide, darolutamide)
    • overcome drug resistance
  • YIV-818-E (Women’s Health): prevents and treats breast cancer (including triple negative breast cancer)

Mechanisms of Action:

  • YIV-818 acts on multiple targets to:
    • modulate hormones,
    • repair DNA damage,
    • regulates cell cycle,
    • modulates epigenetic factors