PIPELINE
Innovative, Systems Biology Medicines
Pre-clinical
Phase I
Phase IIa
Phase IIb
Phase III
Indication
| Pre-clinical | Phase I | Phase IIa | Phase IIb | Phase III |
|---|
Liver Cancer
YIV-906 + Sorafenib: Treating Hepatitis B(+) Hepatocellular Carcinoma Patients
YIV-906 + Capecitabine
YIV-906 + Anti-PD-1
Pancreatic Cancer
YIV-906 + Capecitabine
Colorectal Cancer
YIV-906 + Irinotecan
YIV-906 + Irinotecan / Fluorouracil / Leucovorin
Rectal Cancer
YIV-906 + Chemo-Radiation
Non-Small Cell Lung Cancer
YIV-906 + Anti-PD-1
Melanoma
YIV-906 + Anti-PD-1
YIV-906 + Anti-PD-1/CTLA-4
YIV-906 + Anti-PD-L1
Inflammatory Bowel Disease
YIV-906
Irritable Bowel Syndrome
YIV-906
Lung Cancer
YIV-111
Pulmonary Fibrosis
YIV-111
Breast Cancer
YIV-818
Prostate Cancer
YIV-818
Indication: Solid Tumors (as adjuvant)
- Promising clinical data suggests that YIV-906 could help prolong survival and improve quality of life.
- YIV-906 could become the backbone for cancer therapies – by improving the therapeutic index for a broad spectrum of cancer regimens, including immunotherapies, cell therapies, chemotherapies, and radiation.
Mechanisms of Action: Immunomodulator + Cytoprotector
- YIV-906 turns cold tumors hot and potentiates anti-tumor activity by acting as immumomodulator in the tumor microenvironment
- priming the tumor microenvironment,
- overcoming immune resistance,
- enhancing innate immunity,
- enhancing adaptive immunity
- YIV-906 helps reduce non-hematological side-effects and speed up recovery by acting as a cytoprotector in the GI by:
- reducing intestinal inflammation,
- promoting damaged tissue repair
Regulatory Status
- FDA has granted two Orphan Drug Designations for hepatocellular carcinoma and pancreatic cancer.
Current Clinical Trial – Completed 2025
- Enrolling hepatocellular carcinoma patients with hepatitis B (+) in a Phase 2b clinical study, in the US, Mainland China, Hong Kong, and Taiwan
Indication: Inflammatory Bowel Disease (IBD)
- YIV-906 could improve quality of life for IBD patients
Mechanisms of Action: Cytoprotector
- YIV-906 acts as a cytoprotector in the GI by:
- reducing intestinal inflammation,
- promoting mucosal barrier healing,
- modulating bacteria,
- managing pain,
- reducing colitis pathology
Indications: Respiratory Diseases
- YIV-111 could prevent or treat lung diseases and their progression (from chronic inflammation to pulmonary fibrosis to cancer)
Mechanisms of Action
- YIV-111 acts on multiple targets to:
- reduce inflammation
- reduce fibrosis
- reduce oxidative stress
- reduce bacterial virulence
- reduce viral virulence
Indications: Hormone-driven Diseases
- YIV-818 is a first-in-class systems biology drug that could hormone-driven cancers and their disease progression
- YIV-818-A (Men’s Health): prevents and treats prostate cancer. Potential to:
- boost the efficacy of androgen receptor drugs (including enzalutamide, apalutamide, darolutamide)
- overcome drug resistance
- YIV-818-E (Women’s Health): prevents and treats breast cancer (including triple negative breast cancer)
Mechanisms of Action:
- YIV-818 acts on multiple targets to:
- modulate hormones,
- repair DNA damage,
- regulates cell cycle,
- modulates epigenetic factors

